Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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A clinicopathological study of 20 cases and review of the literature. Dr Sampurna Roy MD.

Magnetic resonance imaging MRI demonstrated diffuse wall thickening of the gallbladder by viewing high signal foci with signal void lesions Fig. Dissection between the gallbladder serosa and hepatic parenchyma was difficult. Accessed December 31st, The pathologic findings showed the collection of foamy histiocytes containing abundant xanthograunlomatous in the cytoplasm and admixed lymphoid cells.

Xanthogranulomatous cholecystitis Diagnosis in short Xanthogranulomatous cholecystitis.

A Case of Xanthogranulomatous Cholecystitis

Ultrasonographic examination showed an inhomogenous, hypoechoic wall thickening of the gallbladder with internal small stones, and no dilatation of intrahepatic bile ducts. Histologically, the nodules are predominantly composed of abundant lipid-laden macrophages, inflammatory cells and fibroblasts.

Click here for information on linking to our website or using our content or images. More recently, these terms, together with other labels, such as ceroid granuloma, ceroid-like histiocytic granuloma of the gallbladder pf and biliary granulomatous cholecystitis 3have been abandoned in favor of XGC, a descriptive term first used by McCoy et al 4. Navigation menu Personal tools Log in.


Despite the possible association between XGC and gallbladder cancer, XGC is not believed to be a premalignant lesion Coagulation profiles were PT Navigation Main page Recent changes Random page Help. J Minim Canthogranulomatous Surg 9 3: Acute cholecystitis ; Acalculous cholecystitis ; Emphysematous cholecystitis ; Eosinophilic Cholescystitis ; Necrobiotic Xanthogranuloma of the the skin. Benign tumors and pseudotumors of the gallbladder: On intraoperative cholangiogram through the cystic duct after cholecystectomy, there was no evidence of xanthogranulomaous stone or bile duct dilatation.

Radiologic findings in xanthogranulomatous cholecystitis. The reason for this association is not clear.

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Soft Tissue Tumour Online. XGC is characterized grossly by irregular wall thickening of the gallbladder associated with the formation of yellowish nodules. Xxnthogranulomatous Xanthogranulomatous cholecystitis XGC is an uncommon, focal or diffuse destructive inflammatory disease of the gallbladder that is assumed to be a variant of conventional chronic cholecystitis.

No metaplasia, nuclear atypia or dysplasia is apparent. Cross sections through the wall revealed multiple yellow-colored, nodule-like lesions ranging from 0. Ceroidlike histiocytic granulomas of gallbladder. Xanthogranulomatous cholecystitis mimicking gallbladder cancer: Foamy macrophages or macrophages with ceroid, bile or iron Also cholesterol clefts and multinucleated giant cells May be focal, nodular or diffuse May contain lymphocytes, plasma cells, foreign body giant cells and neutrophils.

Nippon Geka Gakkai Zasshi. XGC may be difficult to distinguish clinically from acute or chronic cholecystitis; radiologically, it is difficult to distinguish from gallbladder cancer. The patient was discharged on postoperative day 10 without complications. Carcinoma of gallbladder Granulomatous cholecystitis Inflammatory myofibroblastic tumor Sarcoma. J Radiol Case Rep 5 4: Xanthogranulomatous cholecystitis ; Gallbladder cancer. Gallbladder Cholecystitis Xanthogranulomatous cholecystitis Author: CASE A year-old male was admitted to our hospital with a day history of right upper quadrant pain with fever.


Pathology of Xanthogranulomatous Cholecystitis. XGC may be a high risk of postoperative wound infection and other septic complications because of frequent adhesion and abscess formation.

The true incidence of XGC is difficult to establish because this disease is apparently a rare condition, although retrospective estimates of the incidence in cholecystectomy specimens range from 0. Gastroenterol Res Pract It has been suggested that xanthogranulomatous cholecystitis can be divided into two forms: Postgrad Med J ; A clinical and pathologic study of twelve cases.

But XGC imitates gallbladder cancer in various ways. Address reprint requests to: Lipid is ingested by macrophages, which have the appearance of xanthoma cells and giant cells of foreign- body and Touton type. Therefore, obstruction by stones and intraluminal stasis of bile have also been implicated as other important factors 9. It means that both XGC and gallbladder cancer are complications of gallstone and inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall J Am Coll Surg.

The precursor lesions of invasive gallbladder carcinoma.